when you install from the RPM Wine is pretty much all configured for you, so there really isnt a need to use the install/setup scripts. after you install the RPM just open a terminal with your usingname (not root) and type "wine" and it will create the wine environment for your user (which will be in ~/.wine). on occasion i find it necessary to tweak the Wine environment (native/builtin dll's, win version, etc...). normally there is a file called "config" in "~/.wine.config" that contains the settings for your environment. if you dont find it there i have also found it in either /etc or /etc/wine (dont remember which and im not at any of my linux boxes). if its not in ~/.wine i find it and copy to there.
I am root. If you see me laughing you better have a backup.