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It depends...
It depends...
I noticed a single IP repeatedly spamming users on my server, put in the firewall rule and bam not more spam from him.
If its from various sources, you should use spamassassin. If you use postfix you should look at amavisd-new, it is a mail scanner that integrates with spamamassisin and any virus scanner you have (I use ClamAV).
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