I am new to Linux so I've installed all desktop environments on F16 to give them a spin, following instructions on Missing Box studio.
After a while I settled on KDE, so I tried to remove the other DEs completely.
However, I noticed I still have a bunch of gnome packages on my computer.
'sudo yum remove gnome*'
More knowledgeable people warned it will leave me with a broken system because Gnome is too deeply intertwined with Fedora. However, I want to reinstall soon anyway, so....
The executed code took several hundred MBs off my system, mostly Gnome packages, along with a bunch of libraries and some dependencies that had KDE in the name. However, surprise, surprise, everything still works, so far.
Actually, it works better. Default RAM usage is down by 60 MB, and finally all the apps behave according to settings I specified in 'System Settings'.

but
Just thought it might be interesting.