I've been using it on several test machines without issue. I might have just been lucky, and none of these machines has anything important. I've been using it with both Fedora and Ubuntu without ill effects.
That being said, however, it's still relatively new. You might want to wait awhile and see what happens, but so far, as Peacepunk said, I haven't heard any screams of rage.
The only thing to keep in mind is that Fedora's grub can't boot ext4. This seems to be getting people with the live CDs which require an ext2 or 3 /boot and ext4 / (because it's actually a complete O/S image, it has to install on ext4.)
However, with the DVD or installation CD set, that's not an issue, you can install ext3.
It does seem to be so far, so good, but of course, that's what the man said after jumping off the cliff.