I've just installed F8 and everything is working out of the box. The only small problem I have is that instead of the nice mouse pointer icon we were used to since FC6, I have very the very old arrow style that resembles the one I had 10 years ago.
I'm using KDE and I didn't install GNOME. For the rest the mouse is properly working, but very badly looking! The last piece of info is that, I'm keeping the same home folder I had with FC7, so maybe this is an incompatibility issue with some previous version and I have to remove some configuration folders.
Thanks for helping!