got an ink jet?
print it both ways and see what looks better to you?
Or take both files over to a color copy shop and print both to see what you like best.
I would suggest that you stay away from solid colors, that is going to make your job a lot more expensive, simulate colors with cmyk The rip at the printer you are usuing should convert your rgb on the fly. Unless you have very critical standards for color it's going to be a "crap shoot" no matter what you do. To get it right you have to have the whole process calibrated from the KB to the bindery. Not to many jobs like that any more unless it's for a magazine or high end long run print job. If it's that, you probably wouldn't be asking in here ? I've done jobs with OpenOffice and the client loved it! I use inksacpe all the time now for line art jobs and 1 spot color. I might get to use it more if I could figure out how to due a separation with it. Oh, I'm sure there is a way, I just don't know if I can figure it out.
Best of Luck,
Freedom is never Free.